Lithium Hydroxide → HCID 23069970, compound

HRID 1623634Notes

Reaction equation

HRID 1623634 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:7]([CH:12]=1)[C:8]([O:10]C)=[O:9])#[N:2].[OH-].[Li+]>C1COCC1.O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:7]([CH:12]=1)[C:8]([OH:10])=[O:9])#[N:2]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 18973896HCID 18973896, compound

Product 1

HCID 23069970HCID 23069970, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of methyl 5-cyano-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 13; 200 mg, 0.75 mmol) in THF (2 ml) was added a solution of lithium hydroxide (94 mg, 2.25 mmol) in water (8 ml). The reaction mixture was stirred at room temperature overnight. The THF was removed and the mixture was adjusted to pH 7 with 2N HCl. The mixture was filtered and the residue dried to yield the title compound as a yellow solid. 160 mg.

Workup

  1. customThe THF was removed
  2. filtrationThe mixture was filtered
  3. customthe residue dried

Sources & evidence

ORD record
ord-58b71f5ce4fd4a7caac558c7702de979
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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