反应详情

A mixture of methyl 2,5-dihydroxybenzoate (2.5 g, 14.87 mmol), potassium carbonate (25 g, 181 mmol), and dry acetone (150 ml) was stirred at room temperature for 30 min. 4-Methylbenzenesulfonyl chloride (2.86 g, 15.00 mmol) was added portionwise and the mixture was refluxed for 7 h. (Bromomethyl)benzene (6.35 g, 37.2 mmol) was added and the resulting mixture was refluxed overnight. After cooling, the precipitate was filtered, and the filtrate was evaporated. The residue was loaded onto a silica gel column, and was eluted with petroleum ether:ethyl acetate=4:1 to yield the title compound as a white solid. 2.6 g.

1. additionwas added
2. temperaturethe resulting mixture was refluxed overnight
3. temperatureAfter cooling
4. filtrationthe precipitate was filtered
5. customthe filtrate was evaporated
6. washwas eluted with petroleum ether