Hydrochloric Acid → 1,3-Benzenedicarboxylic acid, 4-(phenylmethoxy)-

HRID 1623671Notes

Reaction equation

HRID 1623671 reaction equation
[Li+].[OH-].[C:3]1([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([O:19]CC3C=CC=CC=3)=[O:18])=[CH:13][C:12]=2[C:27]([O:29]CC2C=CC=CC=2)=[O:28])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl>O.O1CCCC1>[C:3]1([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([OH:19])=[O:18])=[CH:13][C:12]=2[C:27]([OH:29])=[O:28])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67107207HCID 67107207, compound

Product 1

HCID 87068451,3-Benzenedicarboxylic acid, 4-(phenylmethoxy)-

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of LiOH (6.12 g, 146 mmol) in water (100 ml) was added to a stirred solution of bis(phenylmethyl) 4-[(phenylmethyl)oxy]-1,3-benzenedicarboxylate (may be prepared as described in Description 47; 6.6 g, 14.59 mmol) in tetrahydrofuran (25 ml) at room temperature. The mixture was stirred at room temperature overnight. The reaction mixture was acidified with concentrated HCl. The white precipitate was collected by filtration, and dried to yield the title compound as a white solid. 3.8 g.

Workup

  1. filtrationThe white precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-1ea220bac9604897a7afe4cc81e0aa73
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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