Lithium Hydroxide → HCID 69937006, compound

HRID 1623827Notes

Reaction equation

HRID 1623827 reaction equation
[OH-].[Li+].[C:3]1([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])=[CH:13][C:12]=2[C:24]([NH:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[O:25])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCCC1.O>[C:3]1([CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])=[CH:13][C:12]=2[C:24]([NH:26][C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)=[O:25])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67107295HCID 67107295, compound

Product 1

HCID 69937006HCID 69937006, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

Lithium hydroxide (9.24 mg, 0.39 mmol) was added to a solution of ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate (may be prepared as described in Example 87; 52 mg, 0.13 mmol) in tetrahydrofuran (2 ml) and water (0.5 ml) and the mixture was stirred overnight. The reaction mixture was purified by MDAP to yield the title compound as a golden solid. 62 mg.

Workup

  1. customThe reaction mixture was purified by MDAP

Sources & evidence

ORD record
ord-596c731d2a4749a898ce244f29cced42
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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