Phenylacetic Acid → 5-bromo-1-(phenylacetyl)-2,3-dihydro-1H-indole

HRID 162550Notes

Reaction equation

[Br:44][c:45]1[cH:46][c:47]2[c:51]([cH:52][cH:53]1)[NH:50][CH2:49][CH2:48]2.[CH3:54][N:55]([CH3:56])[CH:57]=[O:58].[CH:35]([N:36]([CH2:37][CH3:38])[CH:39]([CH3:40])[CH3:41])([CH3:42])[CH3:43].[OH:1][C:2](=[O:3])[CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1.[P-:11]([F:12])([F:13])([F:14])([F:15])([F:16])[F:17].[n:18]1([O:19][C:20]([N:21]([CH3:22])[CH3:23])=[N+:24]([CH3:25])[CH3:26])[c:27]2[n:28][cH:29][cH:30][cH:31][c:32]2[n:33][n:34]1>>[C:2](=[O:3])([CH2:4][c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[N:50]1[CH2:49][CH2:48][c:47]2[cH:46][c:45]([Br:44])[cH:53][cH:52][c:51]21

Participants

Reactant 6

HCID 999Phenylacetic Acid

HCID 6228Dimethylformamide

HCID 9886Hexafluorophosphate

HCID 81531Diisopropylethylamine

HCID 34115665-Bromoindoline

HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium

Product 1

HCID 668241055-bromo-1-(phenylacetyl)-2,3-dihydro-1H-indole

Sources & evidence

ORD record: ord-912f7f373ac042279c90b70e07041009
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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