反应详情

温度

90 °C

The compound obtained in step 1 of Example 36 (1.8 g) was dissolved in N,N-dimethylformamide (40 ml), and potassium acetate (1.7 g) and lithium chloride (0.3 g) were added. After replacing the atmosphere in the system with nitrogen, palladium acetate (0.13 g) and 1-trimethylsilyl-1-propyne (4.3 ml) were added and the mixture was stirred at 90° C. for three days. The reaction solution was cooled to room temperature and then N,N-dimethylformamide was distilled off. The resulting residue was diluted with ethyl acetate and then washed with brine. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated to give the crude title compound (2.4 g).

1. additionwere added
2. temperatureThe reaction solution was cooled to room temperature
3. distillationN,N-dimethylformamide was distilled off
4. additionThe resulting residue was diluted with ethyl acetate
5. washwashed with brine
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. customthe solvent was evaporated