Hydrochloric Acid → HCID 66679852, compound

HRID 1626744Notes

Reaction equation

HRID 1626744 reaction equation
C1COCC1.[OH-].[Na+].[C:8]12([C:18]3[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=3)[O:21][CH2:22][C:23]([O:25]CC)=[O:24])[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2.Cl>O>[C:8]12([C:18]3[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=3)[O:21][CH2:22][C:23]([OH:25])=[O:24])[CH2:15][CH:14]3[CH2:16][CH:10]([CH2:11][CH:12]([CH2:13]3)[CH2:17]1)[CH2:9]2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 86661491HCID 86661491, compound

Product 1

HCID 66679852HCID 66679852, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 mL of THF and 0.65 mL of 1N aqueous sodium hydroxide solution were added to 110 mg (0.35 mmol) of ethyl [3-(adamantan-1-yl)phenoxy]acetate at room temperature, and the mixture was stirred for 6 hours. 1N hydrochloric acid was added to acidify the reaction mixture, and water was added. The precipitated solids were collected by filtration, washed with water, and air-dried, thereby giving 90 mg of [3-(adamantan-1-yl)phenoxy]acetic acid (yield: 89%).

Workup

  1. additionwas added
  2. filtrationThe precipitated solids were collected by filtration
  3. washwashed with water
  4. customair-dried

Sources & evidence

ORD record
ord-3451127c1a3a4cafac3b2574c2b77972
Source dataset
uspto-grants-2014_07
Patent number
US08785473B2

Reaction notes

Loading…