Sodium Sulfide → HCID 178494291, compound

HRID 1630713Notes

Reaction equation

HRID 1630713 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([O:19][CH3:20])[N:3]=1.[S-2:21].[Na+].[Na+]>CN(C=O)C>[OH:16][C:13]1[CH:14]=[CH:15][C:10]([C:6]2[C:7]([C:8]#[N:9])=[C:2]([SH:21])[N:3]=[C:4]([O:19][CH3:20])[C:5]=2[C:17]#[N:18])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 14804Sodium SulfideHCID 136337800HCID 136337800, compound

Product 1

HCID 178494291HCID 178494291, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.3 g (4.550 mmol) of 2-chloro-4-(4-hydroxyphenyl)-6-methoxypyridine-3,5-dicarbonitrile are initially charged in 10 ml of DMF, 426 mg (5.460 mmol) of sodium sulphide are added and the mixture is stirred at room temperature overnight. The reaction mixture is reacted further without any further purification.

Workup

  1. customThe reaction mixture is reacted further without any further purification

Sources & evidence

ORD record
ord-aeeee55435c1442ab4cc263de3de1681
Source dataset
uspto-grants-2014_07
Patent number
US08791146B2

Reaction notes

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