反应详情

53 mg of sodium hydride in 3 ml of tetrahydrofuran are added to 300 mg of (2-bromobenzyl)cyclopropylamine in 2 ml of tetrahydrofuran with ice-cooling. 207 μl of iodomethane are subsequently added, and the mixture is heated at 600 for 1 h. The mixture is allowed to cool and poured onto 20 g of ice and 5 ml of 1N hydrochloric acid, washed 4 times with 10 ml of ethyl acetate each time, and the combined organic phases are dried over sodium sulfate. After filtration, the filtrate is evaporated to dryness.

1. temperaturecooling
2. temperaturethe mixture is heated at 600 for 1 h
3. temperatureto cool
4. washwashed 4 times with 10 ml of ethyl acetate each time
5. dry with materialthe combined organic phases are dried over sodium sulfate
6. filtrationAfter filtration
7. customthe filtrate is evaporated to dryness