Hydrochloric Acid → HCID 56943678, compound

HRID 1631158Notes

Reaction equation

CN([C:4]([O:8]N1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:23][N:24]1[CH2:29][CH2:28]OC[CH2:25]1.[NH2:30][C:31]1[N:40]=[C:39]([C:41]([N:43]2[CH2:51][C:50]3[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=3)[CH2:44]2)=[O:42])[C:38]2[C:33](=[CH:34][CH:35]=[C:36]([C:52]3[CH:57]=[C:56]([F:58])[C:55]([F:59])=[CH:54][C:53]=3[CH2:60][NH2:61])[CH:37]=2)[N:32]=1.Cl>CN(C=O)C>[NH2:30][C:31]1[N:40]=[C:39]([C:41]([N:43]2[CH2:44][C:45]3[C:50](=[CH:49][CH:48]=[CH:47][CH:46]=3)[CH2:51]2)=[O:42])[C:38]2[C:33](=[CH:34][CH:35]=[C:36]([C:52]3[CH:57]=[C:56]([F:58])[C:55]([F:59])=[CH:54][C:53]=3[CH2:60][NH:61][C:4](=[O:8])[CH2:28][CH2:29][N:24]([CH3:23])[CH3:25])[CH:37]=2)[N:32]=1

Participants

Conditions

Temperature: 22 °C

Procedure

85 mg of TBTU (O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate), 112 μl of 4-methylmorpholine and 100 mg of [2-amino-6-(2-aminomethyl-4,5-difluorophenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone are added to a solution of 43 mg of 3-dimethylaminopropionocarboxylic acid hydrochloride in 1 ml of DMF. The mixture is stirred at 22° C. for 16 h, and the product is isolated directly by column chromatography.

Workup

customthe product is isolated directly by column chromatography

Sources & evidence

ORD record: ord-a3f7a711dcc34819b9fa46621b2e1fb7
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08791129B2

Reaction notes

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