反应详情

Indanylglycine-Val-OAllyl (0.46 g, 1.3 mmol) and Z-L-Asp(OtBu)-OH (0.425 g, 1.3 mmol) were solvated in CH2Cl2 (4.5 mL) followed by addition of 4-methylmorpholine (1.45 mL, 1.01 eq), DMAP (14 mg, 0.09 eq) then EDC (0.251 g, 1.01 eq). The mixture was stirred for 1 hour 40 min. Then it was extracted using CH2Cl2/brine. The organic layer was dried over MgSO4, concentrates and purified by silica using a gradient of EtOAc/Hexane (10 to 80%) to get 0.578 g of the desired compound.

1. extractionThen it was extracted
2. dry with materialThe organic layer was dried over MgSO4, concentrates
3. custompurified by silica using a gradient of EtOAc/Hexane (10 to 80%)