Sodium Bicarbonate → (1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester

HRID 1631899Notes

Reaction equation

HRID 1631899 reaction equation
[CH2:1]([N:8]1[C:12]([CH3:13])=[C:11]([CH2:14][C:15]([OH:17])=[O:16])[C:10]([CH3:18])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]([O-])(O)=O.[Na+]>Cl>[CH3:19][O:16][C:15](=[O:17])[CH2:14][C:11]1[C:10]([CH3:18])=[N:9][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:12]=1[CH3:13]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 1080743(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid

Product 1

HCID 61381146(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid methyl ester

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-acetic acid (1.00 g, 4.1 mmol) was dissolved in 3N methanolic HCl (7.5 mL) and stirred at room temperature for 18 h. The reaction mixture was neutralized with aqueous NaHCO3 solution and extracted with dichloromethane. The organic layer was dried over MgSO4 and concentrated under reduced pressure.

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-aca3649779f649fdb54c7714a0f9b6cc
Source dataset
uspto-grants-2014_07
Patent number
US08791272B2

Reaction notes

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