Trifluoroacetic acid → HCID 22224850, compound

HRID 1635249Notes

Reaction equation

HRID 1635249 reaction equation
[O:1]=[C:2]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[C:13](O)([C:15](F)(F)F)=O.[C:20](OC(C(F)(F)F)=O)(C(F)(F)F)=O>CC(C)=O>[CH3:20][C:13]1([CH3:15])[O:5][C:4](=[O:6])[CH:3]=[C:2]([C:7]2[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=2)[O:1]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 9845Trifluoroacetic anhydrideHCID 155112043-Oxo-3-(pyridin-4-yl)propanoic acid

Product 1

HCID 22224850HCID 22224850, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Prepared from 3-oxo-3-pyridin-4-yl-propionic acid [prepared from 4-acetylpyridine, magnesium methylcarbonate and CO2 in DMF at 120° C. according to Journal of Antibiotics 1978, 31, 1245] by treatment with acetone, TFA and TFAA according to general procedure J (method b). Obtained as a white solid (1.3 g).

Sources & evidence

ORD record
ord-dc62d72163c34715a26252ad541ef677
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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