Water → 4-phenyl-1-(triphenylmethyl)-1H-imidazole

HRID 1636572Notes

Reaction equation

HRID 1636572 reaction equation
[C:1]1([C:7](Cl)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:21]1([C:27]2[N:28]=[CH:29][NH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.O>CN(C)C=O.C(N(CC)CC)C>[C:21]1([C:27]2[N:28]=[CH:29][N:30]([C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH:31]=2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

6

Reactant 3

HCID 962WaterHCID 6456Trityl chlorideHCID 178418822HCID 178418822, compound

Product 1

HCID 102217694-phenyl-1-(triphenylmethyl)-1H-imidazole

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8471TriethylamineSolvent

Procedure

7.6 mmol of triphenylmethyl chloride in 150 ml of dimethylformamide are added, under an argon atmosphere, to a solution of 6.9 mnmol of 4-phenyl-1H-imidazole in 50 ml of dimethylformamide and 10 ml of triethylamine. The solution is stirred for 4 hours at ambient temperature. After the addition of water, the precipitate obtained is triturated in ethyl ether, filtered and then dried, enabling the product obtained to be isolated.

Workup

  1. customthe precipitate obtained
  2. customis triturated in ethyl ether
  3. filtrationfiltered
  4. customdried
  5. customobtained
  6. customto be isolated

Sources & evidence

ORD record
ord-972e1ee42a734647b46820531e854369
Source dataset
uspto-grants-2000_03
Patent number
US06034250

Reaction notes

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