HRID1637633

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1c(SCCCSc2ccc3ncc([N+](=O)[O-])n3n2)ccnc1CCl

HCID18799383

未命名化合物

HCID178527768

未命名化合物

PRODUCTS

生成物

结构：Cc1c(SCCCSc2ccc3ncc([N+](=O)[O-])n3n2)ccnc1CSc1nc2cc(-c3nccs3)ccc2[nH]1.Cl

HCID178431909

未命名化合物

收率 62.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

0.77 g (1.87 mmol) of 6-[3-(2-chloromethyl-3-methylpyridin-4-ylsulfanyl)propylsulfanyl]-3-nitro-imidazo[1,2-b]pyridazine and 0.35 g (1.5 mmol) of 6-thiazol-2-yl-1H-benzimidazole-2-thiol in 25 ml of isopropanol and 20 ml of dimethylformamide are reacted as described in Example 2. 0.60 g (62%) of the title compound of m.p. 232-234° C. is isolated.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f76827dc312d4a3d81664feb5379e718
来源数据集: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06043242
来源说明: uspto-grants-2000_03

反应 SMILES

[Cl:1][CH2:2][C:3]1[C:8]([CH3:9])=[C:7]([S:10][CH2:11][CH2:12][CH2:13][S:14][C:15]2[CH:16]=[CH:17][C:18]3[N:19]([C:21]([N+:24]([O-:26])=[O:25])=[CH:22][N:23]=3)[N:20]=2)[CH:6]=[CH:5][N:4]=1.[S:27]1[CH:31]=[CH:30][N:29]=[C:28]1[C:32]1[CH:33]=[CH:34][C:35]2[N:39]=[C:38]([SH:40])[NH:37][C:36]=2[CH:41]=1>C(O)(C)C.CN(C)C=O>[ClH:1].[CH3:9][C:8]1[C:3]([CH2:2][S:40][C:38]2[NH:39][C:35]3[CH:34]=[CH:33][C:32]([C:28]4[S:27][CH:31]=[CH:30][N:29]=4)=[CH:41][C:36]=3[N:37]=2)=[N:4][CH:5]=[CH:6][C:7]=1[S:10][CH2:11][CH2:12][CH2:13][S:14][C:15]1[CH:16]=[CH:17][C:18]2[N:19]([C:21]([N+:24]([O-:26])=[O:25])=[CH:22][N:23]=2)[N:20]=1