Tryptamine → HCID 18363100, compound

HRID 1637869Notes

Reaction equation

HRID 1637869 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[F:13][C:14]([F:25])([F:24])[O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1.C(O)(C(F)(F)F)=O>>[F:13][C:14]([F:24])([F:25])[O:15][C:16]1[CH:17]=[CH:18][C:19]([CH:20]2[C:5]3[NH:6][C:7]4[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:4]=3[CH2:3][CH2:2][NH:1]2)=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 1150TryptamineHCID 6422Trifluoroacetic acidHCID 69573p-(Trifluoromethoxy)benzaldehyde

Product 1

HCID 18363100HCID 18363100, compoundYield 38.5%

Procedure

This product was prepared using the same procedure as for Intermediate 1 with tryptamine (2.0 g, 12.5 mmol), 4-trifluoromethoxybenzaldehyde (2.4 g, 1 equiv.) and TFA (1.9 mL, 2 equiv.) to give the title compound (1.6 g, 38%) as a white powder. MP: 68-69° C.

Workup

  1. customThis product was prepared

Sources & evidence

ORD record
ord-7bb4bc6957934fd4a2595c1d5faa9d3e
Source dataset
uspto-grants-2000_03
Patent number
US06043252

Reaction notes

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