Tryptamine → HCID 5150055, compound

HRID 1637878Notes

Reaction equation

HRID 1637878 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH:17]=O.C(O)(C(F)(F)F)=O>>[F:13][C:14]1[CH:15]=[C:16]([CH:17]2[C:5]3[NH:6][C:7]4[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:4]=3[CH2:3][CH2:2][NH:1]2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

Participants

4

Reactant 3

HCID 1150TryptamineHCID 6422Trifluoroacetic acidHCID 676963-Fluoro-p-anisaldehyde

Product 1

HCID 5150055HCID 5150055, compoundYield 59%

Procedure

This product was prepared using the same procedure as for Intermediate 1 with tryptamine (4.80 g, 30.0 mmol), 3-fluoro-4-methoxybenzaldehyde (4.86 g, 1.05 equiv.) and TFA (4.6 mL, 2 equiv.) to give the title compound (5.2 g, 59%) as white crystals. MP: 68° C.

Workup

  1. customThis product was prepared

Sources & evidence

ORD record
ord-e8267aa8ed3c40a3b7421555fe237326
Source dataset
uspto-grants-2000_03
Patent number
US06043252

Reaction notes

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