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HRID1637961

反应详情

EQUATION

反应方程式

HRID 1637961 的结构方程式

REACTANTS

反应物

5
反应SMILES：O=C(O)c1ccc(Br)cc1
HCID11464

4-Bromobenzoic acid

C7H5BrO2

反应SMILES：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

反应SMILES：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

反应SMILES：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

反应SMILES：CC(=O)N1C(=O)Cc2cc([N+](=O)[O-])ccc21
HCID2839329

1-Acetyl-5-nitroindolin-2-one

C10H8N2O4

PRODUCTS

产物

1
反应SMILES：CC(=O)N1C(=O)C(=C(O)c2ccc(Br)cc2)c2cc([N+](=O)[O-])ccc21
HCID178473959

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 10(a) from 1-acetyl-5-nitro-2-indolinone and 4-bromo-benzoic acid in dry DMF in the presence of TBTU, HOBT and Hunig's base (20° C., overnight) and evaporation in vacuo. A sample of the crude product obtained was purified by column chromatography on silica gel with CH2Cl2 /MeOH (20:1) as eluant.