HRID1637965

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID323719

1-acetylindolin-2-one

C10H9NO2

HCID747553

4-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzoic acid

C16H11NO4

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

PRODUCTS

生成物

结构：CC(=O)N1C(=O)C(=C(O)c2ccc(CN3C(=O)c4ccccc4C3=O)cc2)c2ccccc21

HCID178473967

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Prepared analogously to Example 10(a) from 1-acetyl-2-indolinone and 4-phthalimidomethyl-benzoic acid (melting point: 260-262° C.) in dry DMF in the presence of TBTU, HOBT and Hrinig's base (20° C., 4 hours), stirring in dilute hydrochloric acid, extracting with CH2Cl2, evaporating the dried organic extract in vacuo, triturating the evaporation residue with EtOac and drying the solid substance.

WORKUP

后处理

extractionextracting with CH2Cl2
customevaporating the dried
extractionorganic extract in vacuo
customtriturating the evaporation residue with EtOac
customdrying the solid substance

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-663e3778c8944f07b78ddac3a2816c4e
来源数据集: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06043254
来源说明: uspto-grants-2000_03

反应 SMILES

[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].[C:14]1(=[O:34])[N:18]([CH2:19][C:20]2[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=2)[C:17](=[O:29])[C:16]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:15]12.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.Cl>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:24]([OH:25])[C:23]2[CH:27]=[CH:28][C:20]([CH2:19][N:18]3[C:17](=[O:29])[C:16]4=[CH:30][CH:31]=[CH:32][CH:33]=[C:15]4[C:14]3=[O:34])=[CH:21][CH:22]=2)[C:5]1=[O:13])(=[O:3])[CH3:2]