Isopropanol → p-Toluenesulfonic acid

HRID 1638360Notes

Reaction equation

HRID 1638360 reaction equation
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(O)(C)C>N1C=CC=CC=1>[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 521998p-Toluenesulfonic acid monohydrate

Product 1

HCID 6101p-Toluenesulfonic acid

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

A mixture of 190.0 parts of p-toluene sulfonic acid monohydrate and 419.0 parts of isopropyl alcohol was charged into the same three-necked flask as in Production Example 1 and stirred at room temperature. The resulting solution was added with 79.0 parts of pyridine to obtain a solution of pyridine salt of p-toluene sulfonic acid blocked with equimole of pyridine and having an effective component concentration (aromatic sulfonic acid) of 25%.

Workup

  1. additionwas charged into the same three-necked flask as in Production Example 1

Sources & evidence

ORD record
ord-6e5ede1791314bb6b7e7c55267c49a23
Source dataset
uspto-grants-1989_11
Patent number
US04879337

Reaction notes

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