Potassium Iodide → Hydrochloric Acid

HRID 1639103Notes

Reaction equation

HRID 1639103 reaction equation
[Cl:1][CH2:2][CH2:3][CH:4]([OH:15])[CH2:5][O:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]([CH3:14])[CH:8]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:19][CH:18]=1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CC(O)C.C(O)CCC>[OH2:6].[ClH:1].[CH3:14][C:9]1[CH:8]=[C:7]([CH:12]=[C:11]([CH3:13])[CH:10]=1)[O:6][CH2:5][CH:4]([OH:15])[CH2:3][CH2:2][N:26]1[CH2:25][CH2:24][N:23]([C:20]2[CH:19]=[CH:18][C:17]([F:16])=[CH:22][CH:21]=2)[CH2:28][CH2:27]1.[ClH:1]

Participants

8

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 752601-(4-Fluorophenyl)piperazineHCID 131203444-Chloro-1-(3,5-dimethylphenoxy)-2-butanol

Product 2

HCID 313Hydrochloric AcidHCID 198402441-(3,5-Dimethylphenoxy)-4-[4-(4-fluorophenyl)-1-piperazinyl]-2-butanol monohydrochloride monohydrate

Reagents, catalysts & solvents 2

HCID 2631-ButanolSolventHCID 3776IsopropanolSolvent

Procedure

This compound was prepared according to the procedure of Example 25. A mixture of 2.5 g (0.01 mole) of 4-chloro-1-(3,5-dimethylphenoxy)-2-butanol, 1.8 g (0.01 mole) of 1-(4-fluorophenyl)piperazine, 5.2 g (0.05 mole) of anhydrous sodium carbonate and 0.1 g of potassium iodide in a total volume of 200 ml of 1-butanol gave a golden oil as residue. The hydrochloride was formed in 2-propanol saturated with hydrogen chloride and the collected solid was recrystallized from methanol-water-ethyl ether to give 1.6 g (37%) of white crystalline solid, m.p. 176°-180° C.

Workup

  1. customThis compound was prepared
  2. customgave a golden oil as residue

Sources & evidence

ORD record
ord-7d86332655f44c5ba8ad78a308e22524
Source dataset
uspto-grants-1989_11
Patent number
US04882330

Reaction notes

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