Potassium Carbonate → 4-(2-Fluoro-4-nitrophenoxy)-1,2-benzisoxazole-3-amine

HRID 16397Notes

Reaction equation

HRID 16397 reaction equation
[NH2:1][C:2]1[C:6]2=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=[C:5]2[O:4][N:3]=1.[F:12][C:13]1[CH:14]=[C:15]([N+:20]([O-:22])=[O:21])[CH:16]=[CH:17][C:18]=1F.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[F:12][C:13]1[CH:14]=[C:15]([N+:20]([O-:22])=[O:21])[CH:16]=[CH:17][C:18]=1[O:11][C:7]1[C:6]2[C:2]([NH2:1])=[N:3][O:4][C:5]=2[CH:10]=[CH:9][CH:8]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 1357037053-Aminobenzo[d]isoxazol-4-ol

Product 1

HCID 179792764-(2-Fluoro-4-nitrophenoxy)-1,2-benzisoxazole-3-amine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

94.37 mg (0.63 mmol) of 3-amino-1,2-benzisoxazol-4-ol (from example V), 100 mg (0.63 mmol) of 3,4-difluoronitrobenzene and 95.56 mg (0.69 mmol) of potassium carbonate are suspended in 3 ml of anhydrous dimethylformamide and stirred at room temperature for 16 hours. The reaction solution is then diluted with water, and the precipitate is filtered off. The product is dried under high vacuum.

Workup

  1. filtrationthe precipitate is filtered off
  2. customThe product is dried under high vacuum

Sources & evidence

ORD record
ord-dc5d146c38a84b3dac59f0da5117b260
Source dataset
uspto-grants-2010_06
Patent number
US07737153B2

Reaction notes

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