Hydrochloric Acid → HCID 178498352, compound

To a solution of methyl 3-amino-6-chloro-2-methylbenzoate (25.0 g, 125 mmol) in water (139 mL) were added concentrated hydrochloric acid (26.1 mL, 313 mmol), ammonium tetrafluoroborate (17.1 g, 163 mmol) and sodium nitrite (8.64 g, 125 mmol) at 0° C., and the mixture was stirred for 30 min. The reaction solution was diluted with water, and washed with ethyl acetate. The water of the obtained aqueous layer was evaporated under reduced pressure, and the residue was dissolved in chloroform (287 mL). 18-Crown-6 (993 mg, 3.76 mmol) and potassium acetate (13.5 g, 138 mmol) were added. The reaction mixture was stirred at room temperature for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by flash silica gel column chromatography (ethyl acetate/hexane=1/3) to give the title compound (4.10 g, yield 20%).

1. washwashed with ethyl acetate
2. customThe water of the obtained aqueous layer was evaporated under reduced pressure
3. dissolutionthe residue was dissolved in chloroform (287 mL)
4. stirringThe reaction mixture was stirred at room temperature for 2 hr
5. extractionthe mixture was extracted with ethyl acetate
6. dry with materialThe extract was dried over anhydrous sodium sulfate
7. customthe solvent was evaporated under reduced pressure
8. customThe residue was purified by flash silica gel column chromatography (ethyl acetate/hexane=1/3)

ORD record

ord-67ce72d4955d4501843b51ac2a72a68f

Source dataset

uspto-grants-2012_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08110585B2