反应详情

温度

50 °C

Add 2 g (14.5 mmol) of K2CO3 and 1.16 mL (14.5 mmol) of iodoethane to a solution of 2.45 g (9.6 mmol) of 4-chloro-3-iodophenol in 30 mL of DMF. Heat the reaction mixture at 50° C. while stirring for 3 h, then distribute in 200 mL of ether/water 1:1 mixture. Wash the organic phase with 3×50 mL of water then dry over Na2SO4 and concentrate under reduced pressure. We obtain 2.38 g of 1-chloro-2-iodo-4-ethoxybenzene in the form of oil.

1. washWash the organic phase with 3×50 mL of water
2. dry with materialthen dry over Na2SO4
3. concentrationconcentrate under reduced pressure