Hydrochloric Acid → HCID 66722410, compound

HRID 1639970Notes

Reaction equation

HRID 1639970 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:13][CH2:12][C@:11]2([CH2:18][CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]2)[C:10]1=[O:26]>C(OCC)(=O)C>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:13][CH2:12][C@:11]2([CH2:18][CH2:17][CH2:16][NH:15][CH2:14]2)[C:10]1=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66722471HCID 66722471, compound

Product 1

HCID 66722410HCID 66722410, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride (4.0 M in 1,4-dioxane, 2.0 mL) was added to a solution of tert-butyl (5S)-2-(2-chlorophenyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (0.103 g, 0.000283 mol) in ethyl acetate (0.5 mL) and the mixture was stirred for 2 h. Then the solvent was removed in-vacuo to afford the desired product. LC-MS: 265.2 (M+H)+.

Workup

  1. customThen the solvent was removed in-vacuo

Sources & evidence

ORD record
ord-de83ba5bb9284f17a152319c7276d616
Source dataset
uspto-grants-2012_02
Patent number
US08110581B2

Reaction notes

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