反应详情

80.0 mg (0.23 mmol) 6-(3-methyl-2,5-dioxo-1′,3′-dihydrospiro[imidazolidin-4,2′-inden]-5′-ylamino)pyrimidine-4-carboxylic acid, 30 μL (0.27 mmol) 2,3-dihydro-1H-indole, 70 μL (0.50 mmol) triethylamine and 80.0 mg (0.25 mmol) TBTU in 1.5 mL DMF were stirred for 4 h at RT. The reaction mixture was filtered through a syringe filter and purified by preparative HPLC. The product fractions were combined, concentrated by rotary evaporation and dried.

1. filtrationThe reaction mixture was filtered through a syringe
2. filtrationfilter
3. custompurified by preparative HPLC
4. concentrationconcentrated by rotary evaporation
5. customdried