Trityl chloride → HCID 86643840, compound

HRID 1640984Notes

Reaction equation

HRID 1640984 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]([NH:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)(=[O:17])=[O:16])[CH:13]=2)[NH:8][N:7]=1)=[O:4].Cl[C:28]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.C(N(CC)CC)C>ClCCl>[F:26][C:2]([F:1])([F:25])[C:3]([NH:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)(=[O:16])=[O:17])[CH:13]=2)[N:8]([C:28]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[N:7]=1)=[O:4]

Participants

5

Reactant 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 86643839HCID 86643839, compound

Product 1

HCID 86643840HCID 86643840, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2,2,2-Trifluoro-N-[5-(3-fluoro-benzenesulfonyl)-1H-indazol-3-yl]-acetamide, (17.93 g, 46.33 mmol) in dry dichloromethane (300 mL) was treated with chlorotriphenylmethane (14.22 g, 50.96 mmol) and triethylamine (14.2 mL, 102 mmol). After stirring at room temperature for two days, the reaction was washed with a solution of NH4Cl, dried and evaporated. The crude was used as such in the next step without any further purification.

Workup

  1. washthe reaction was washed with a solution of NH4Cl
  2. customdried
  3. customevaporated
  4. customwithout any further purification

Sources & evidence

ORD record
ord-b6791f4d72b0463091d3181b7d46caa3
Source dataset
uspto-grants-2012_02
Patent number
US08114865B2

Reaction notes

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