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HRID1641322

反应详情

EQUATION

反应方程式

HRID 1641322 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cl.O.O=C1CCNCC1
HCID2723901

Piperidin-4-one--hydrogen chloride--water (1/1/1)

C5H12ClNO2

结构：CC(C)Oc1cccc(CBr)c1
HCID21714701

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)Oc1cccc(CN2CCC(=O)CC2)c1.O
HCID66737812

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of 4-piperidone hydrochloride monohydrate (19.52 g, 127.12 mmol), 1-Bromomethyl-3-isopropoxy-benzene (19.41 g, 84.76 mmol) and K2CO3 in DMF (150 mL) is stirred at rt for 16 hr. Solvent is removed in vacco, the residue is extract (EtOAc/Brine), dried (Na2SO4), concentrated, and purified by chromatography (silica gel, EtoAc/hexanes, 2/3) to afford 14-4. (MH+, 266)

WORKUP

后处理

  1. customSolvent is removed in vacco
  2. extractionthe residue is extract (EtOAc/Brine)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated
  5. custompurified by chromatography (silica gel, EtoAc/hexanes, 2/3)
  6. customto afford 14-4