Triethylamine → HCID 24125144, compound

HRID 1642149Notes

Reaction equation

HRID 1642149 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10](Cl)(=[O:12])=[O:11])=[C:5]([CH3:14])[C:4]=1[CH3:15].[CH3:16][NH:17][CH2:18][CH2:19][C:20]#[N:21].C(N(CC)CC)C.C(OCC)(=O)C>C1COCC1>[C:20]([CH2:19][CH2:18][N:17]([CH3:16])[S:10]([C:6]1[C:7]([CH3:9])=[CH:8][C:3]([O:2][CH3:1])=[C:4]([CH3:15])[C:5]=1[CH3:14])(=[O:12])=[O:11])#[N:21]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 69656Propanenitrile, 3-(methylamino)-HCID 5627874-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride

Product 1

HCID 24125144HCID 24125144, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride (5.00 g, 20 mmol) was added at room temperature to a solution of 3-methylaminopropionitrile (1.50 g, 18.3 mmol) and triethylamine (5.50 g, 55 mmol) in THF (30 ml), and stirring was carried out for 16 h. Ethyl acetate (50 ml) was then added to the reaction mixture, and washing with sodium hydrogen carbonate solution (3×50 ml) was carried out. The organic phase was dried over sodium sulfate and concentrated in vacuo.

Workup

  1. washwashing with sodium hydrogen carbonate solution (3×50 ml)
  2. dry with materialThe organic phase was dried over sodium sulfate
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1e166e30b00044bc8b40789a42526406
Source dataset
uspto-grants-2012_02
Patent number
US08119633B2

Reaction notes

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