反应详情

温度

155 °C

To a stirred solution of Compound 174 (450 mg, 1.06 mmol) in anhydrous and degassed DMF (3 mL), were added Pd(OAc)2 (59 mg, 0.26 mmol) and DBU (0.48 mL, 3.18 mmol), under nitrogen. After being stirred for 6 h. at 155° C. the reaction was quenched by addition of water (5 mL). The solid precipitates out was filtered and washed thoroughly with water. The residue was dried under vacuum and purified by flash chromatography to furnish Compound 175 (237 mg, 65%).

1. customwas quenched by addition of water (5 mL)
2. customThe solid precipitates
3. filtrationout was filtered
4. washwashed thoroughly with water
5. customThe residue was dried under vacuum
6. custompurified by flash chromatography