Pyridine-2-carbonitrile → N-Hydroxypicolinimidamide

HRID 1642818Notes

Reaction equation

HRID 1642818 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[N:8].[Cl-].[OH:10][NH3+:11].C(N(CC)CC)C>>[OH:10][N:11]=[C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[NH2:8]

Participants

4

Reactant 3

HCID 7522Pyridine-2-carbonitrileHCID 8471TriethylamineHCID 21645Hydroxylamine HCl

Product 1

HCID 120564N-Hydroxypicolinimidamide

Procedure

1.0 g (9.6 mmol) of pyridine-2-carbonitrile, 1.0 g (14.4 mmol) of hydroxylammonium chloride and 1.6 ml (11.5 mmol) of triethylamine were reacted according to the General Method 5A. Yield: 1.06 g (80% of theory)

Sources & evidence

ORD record
ord-f471a93519bf463e942001a87fdadda8
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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