反应详情

To a stirred solution of 4-bromo-3,5-dihydroxy-benzoic acid (350 g, 1.5 mol) in dry DMF (2 L) were added K2CO3 (725 g, 5.25 mL) and BnBr (769 g, 4.5 mol) in one portion. The mixture was stirred at room temperature for 2 days and then filtered. The filter cake was washed with CH2Cl2. The combined filtrates were concentrated to give the title compound (225 g, 40% yield) as a white solid. 1H NMR (400 MHz, CDCl3): δ 7.22-7.52 (m, 17H), 5.38(s, 2H), 5.21 (s, 4H).

1. filtrationfiltered
2. washThe filter cake was washed with CH2Cl2
3. concentrationThe combined filtrates were concentrated