反应详情

温度

0 °C

Carbonothioic dichloride (2.0E1 uL, 0.00026 mol) was added to a solution of the 6-Amino-pyridine-3-sulfonic acid thiazol-2-ylamide (45 mg, 0.00018 mol) and N,N-Diisopropylethylamine (0.092 mL, 0.00053 mol) in Tetrahydrofuran (1.2 mL, 0.014 mol) at 0° C. under an atmosphere of Argon and was stirred for 40 min at 0° C. Saturated ammonium hydroxide solution was added to the reaction mixture and stirred for a few min, then warmed to ambient temperature. The reaction mixture was concentrated and then dried on a lyophilizer to give the crude product that was used in the next step without purification. Note: The starting material, 6-Amino-pyridine-3-sulfonic acid thiazol-2-ylamide, was TFA salts.

1. stirringstirred for a few min
2. temperaturewarmed to ambient temperature
3. concentrationThe reaction mixture was concentrated
4. customdried on a lyophilizer