Hydrochloric Acid → HCID 11844910, compound

HRID 1645191Notes

Reaction equation

HRID 1645191 reaction equation
C(OC([N:8]1[CH2:13][CH:12]2[CH:10]([CH:11]2[CH2:14][N:15]([C:28]([C:30]2[N:31]=[CH:32][N:33]([CH3:35])[CH:34]=2)=[O:29])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23][C:24]([F:27])([F:26])[F:25])[CH:18]=2)[CH2:9]1)=O)(C)(C)C.[ClH:36]>CCOC(C)=O>[ClH:36].[CH:10]12[CH:11]([CH2:14][N:15]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][C:24]([F:26])([F:27])[F:25])[CH:18]=3)[C:28]([C:30]3[N:31]=[CH:32][N:33]([CH3:35])[CH:34]=3)=[O:29])[CH:12]1[CH2:13][NH:8][CH2:9]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66775648HCID 66775648, compound

Product 1

HCID 11844910HCID 11844910, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 6-{[(1-Methyl-1H-imidazole-4-carbonyl)-(3-trifluoromethoxy-benzyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester prepared above (7.74 gm, 15.65 mmol) was added 5 mL of saturated HCl in EtOAc at room temperature. The reaction stirred at room temperature for 4 hours. The mixture was concentrated under reduced pressure to yield 6.63 gm of 1-Methyl-1H-imidazole-4-carboxylic acid (3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-trifluoromethoxy-benzyl)-amide Hydrochloride.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-50493cc50bd145ab8386b7ddd817bc45
Source dataset
uspto-grants-2012_02
Patent number
US08124639B2

Reaction notes

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