m-Chloroperbenzoic acid → HCID 11716370, compound

HRID 1645381Notes

Reaction equation

HRID 1645381 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH:7]([CH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH2:6]2.ClC1C=CC=C(C(OO)=[O:30])C=1.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH:7]([CH2:15][C:16]1[CH:21]=[CH:20][N+:19]([O-:30])=[CH:18][CH:17]=1)[CH2:6]2

Participants

5

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 100852305,6-Dimethoxy-2-(pyridin-4-ylmethyl)indan-1-one

Product 1

HCID 11716370HCID 11716370, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[(5,6-Dimethoxy-1-indanon-2-yl)methyl]pyridine (1.2 g) was dissolved in methylene chloride (18 ml) and chilled. m-Chloroperbenzoic acid (0.9 g) was added to reaction mixture and then stirred for 4 hours. Reaction mass was stirred with 10% aqueous solution of sodium bicarbonate. The organic layer was separated and washed with 50 ml water. Organic layer was distilled off, title compound is obtained (1.2 g).

Workup

  1. temperaturechilled
  2. customReaction mass
  3. customThe organic layer was separated
  4. washwashed with 50 ml water
  5. distillationOrganic layer was distilled off

Sources & evidence

ORD record
ord-19c517e487684d399488a8cb32151c3d
Source dataset
uspto-grants-2012_02
Patent number
US08124783B2

Reaction notes

Loading…