反应详情

温度

50 °C

That is, after 3-methoxy-3-methyl-2-methylsulfonyloxybutanoic acid (22.6 g, 0.1 mol) and 4,6-dimethoxy-2-mercaptopyrimidine (17.3 g, 0.1 mol) were added to N,N-dimethylformamide (200 ml) and further anhydrous potassium carbonate (13.8 g) was added, the mixture was stirred at 50° C. for 2 hours. The resulting reaction mixture was added to a 1N hydrochloric acid aqueous solution (300 ml), and extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated saline solution and dried over magnesium sulfate, and ethyl acetate was removed under reduced pressure. The crystals obtained were washed with n-hexane to obtain 24.1 g (yield: 80%) of the title compound.

1. additionwas added
2. customThe resulting reaction mixture
3. extractionextracted with ethyl acetate
4. washThe ethyl acetate layer was washed with a saturated saline solution
5. dry with materialdried over magnesium sulfate, and ethyl acetate
6. customwas removed under reduced pressure
7. customThe crystals obtained
8. washwere washed with n-hexane