Ethyl Bromide → HCID 9881736, compound

HRID 1646211Notes

Reaction equation

HRID 1646211 reaction equation
[NH2:1][C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[C:14]1[NH:16][N:17]=[CH:18][C:13]=1[CH2:12][CH2:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.[H-].[Na+].Br[CH2:22][CH3:23]>CN(C=O)C>[NH2:1][C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[C:14]1=[N:16][N:17]([CH2:22][CH3:23])[CH:18]=[C:13]1[CH2:12][CH2:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2

Participants

5

Reactant 3

HCID 6332Ethyl BromideHCID 24758Sodium hydrideHCID 10421619HCID 10421619, compound

Product 1

HCID 9881736HCID 9881736, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 11-amino-4,5-dihydro-1H-pyrazolo[3,4-a]acridine (3.0 g) in dry DMF (90 ml) was added NaH (60%)(0.63 g) slowly. The reaction was stirred at room temperature for a half hour, bromoethane (1.2 ml) was added and the reaction was stirred at room temperature overnight.

Workup

  1. stirringthe reaction was stirred at room temperature overnight

Sources & evidence

ORD record
ord-7efab321181d4013af9021634057015a
Source dataset
uspto-grants-1993_01
Patent number
US05179100

Reaction notes

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