Ethyl bromoacetate → HCID 10019034, compound

HRID 1646213Notes

Reaction equation

HRID 1646213 reaction equation
[NH2:1][C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[C:14]1[NH:16][N:17]=[CH:18][C:13]=1[CH2:12][CH2:11]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>CN(C=O)C>[CH2:26]([O:25][C:23](=[O:24])[CH2:22][N:17]1[CH:18]=[C:13]2[CH2:12][CH2:11][C:10]3[C:15]([C:14]2=[N:16]1)=[C:2]([NH2:1])[C:3]1[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=1)[N:9]=3)[CH3:27]

Participants

5

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 10421619HCID 10421619, compound

Product 1

HCID 10019034HCID 10019034, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 11-amino-4,5-dihydro-1H-pyrazolo[3,4-a]acridine (10 g) in dry DMF (300 ml) was added NaH (60%)(2.12 g) slowly. The reaction was stirred at room temperature for two hours, ethyl bromoacetate (6.0 ml) was added and the reaction was stirred for one hour.

Workup

  1. stirringthe reaction was stirred for one hour

Sources & evidence

ORD record
ord-652a0e3d97f5479c8d3f709e5d1cefa0
Source dataset
uspto-grants-1993_01
Patent number
US05179100

Reaction notes

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