反应详情

To a stirring solution of (2S)-2-hydroxy-4-methylvaleric acid (5.0 g) and benzyl bromide (4.95 ml) in DMF (50 ml) was added potassium carbonate (3.13 g) at room temperature. After being stirred for 12 hours, the solvent was removed by evaporation in vacuo. The residue was dissolved in ethyl acetate (100 ml) and washed with water, 1N HCl and brine successively. The organic layer was dried over magnesium sulfate and concentrated in vacuo. The residual oil was purified with silica gel column chromatography (hexane-ethyl acetate as an eluent) to give benzyl (2S)-2-hydroxy-4-methylvalerate (8.2 g) as a colorless oil.

1. customthe solvent was removed by evaporation in vacuo
2. dissolutionThe residue was dissolved in ethyl acetate (100 ml)
3. washwashed with water, 1N HCl and brine successively
4. dry with materialThe organic layer was dried over magnesium sulfate
5. concentrationconcentrated in vacuo
6. customThe residual oil was purified with silica gel column chromatography (hexane-ethyl acetate as an eluent)