Tetrahydrofuran → 2-anilino-6-fluoro-7-(hydroxymethyl)-1-phenyl-1,8-naphthyridin-4(1H)-one
Reaction equation
[Al+3:32].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[H-:31].[H-:34].[H-:35].[H-:36].[Li+:33].[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][c:10](=[O:30])[c:11]2[cH:12][c:13]([F:29])[c:14]([C:24](=[O:25])[O:26][CH2:27][CH3:28])[n:15][c:16]2[n:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1>>[NH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[cH:9][c:10](=[O:30])[c:11]2[cH:12][c:13]([F:29])[c:14]([CH2:24][OH:25])[n:15][c:16]2[n:17]1-[c:18]1[cH:19][cH:20][cH:21][cH:22][cH:23]1Participants
6
Sources & evidence
- ORD record
- ord-9ef88c7632e74cd69e0f6ec21d63d567
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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