Methanesulfonic Acid → HCID 86748781, compound

HRID 1647493Notes

Reaction equation

HRID 1647493 reaction equation
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[O:24][CH2:25][CH2:26][OH:27])(=[O:5])[CH2:2][CH2:3][CH3:4].[CH3:28][S:29]([OH:32])(=[O:31])=[O:30]>C(OCC)(=O)C>[S:29]([OH:32])(=[O:31])(=[O:30])[CH3:28].[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[O:24][CH2:25][CH2:26][OH:27])(=[O:5])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 9887258HCID 9887258, compound

Product 1

HCID 86748781HCID 86748781, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
50 °C

Procedure

3-Butyryl-4-(2-methylphenylamino)-8-(2-hydroxyethoxy)quinoline (60 g) was suspended in ethyl acetate (400 ml), warmed to 50° C., and methanesulphonic acid (16.3 g) added with vigorous stirring. The desired salt crystallised on cooling, and was filtered off and washed with ethyl acetate; yield 50.1 g, m.p. 83°-85° C.

Workup

  1. customThe desired salt crystallised
  2. temperatureon cooling
  3. filtrationwas filtered off
  4. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-7fa8c75cac4a4ad5a638e060d201174c
Source dataset
uspto-grants-1995_07
Patent number
US05432182

Reaction notes

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