Benzaldehyde → Ethanol, 2-[(1-methylethyl)(phenylmethyl)amino]-

HRID 1647546Notes

Reaction equation

HRID 1647546 reaction equation
C(N(C(C)C)CC[C:7]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1Cl)(CCN1CCCCC1)C(N)=O)(=O)C.[NH2:29][CH2:30][CH2:31][OH:32].[CH:33](=O)[C:34]1C=CC=C[CH:35]=1.[H][H]>[Pt].CC(C)=O.C(O)C>[CH3:33][CH:34]([N:29]([CH2:7][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH2:30][CH2:31][OH:32])[CH3:35]

Participants

8

Reactant 4

HCID 240BenzaldehydeHCID 700EthanolamineHCID 59798BidisomideHCID 178418361HCID 178418361, compound2×

Product 1

HCID 11084730Ethanol, 2-[(1-methylethyl)(phenylmethyl)amino]-

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalyst2×HCID 180AcetoneSolventHCID 702EthanolSolvent

Procedure

The present invention also relates to a process for preparing α-[2-[acetyl(1-methylethyl)amino]ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide which has the following formula: ##STR11## and comprises the steps of: (a) alkylating 2-aminoethanol using benzaldehyde and ethanol in the presence of a platinum catalyst and hydrogen followed by reductive alkylation using acetone in the presence of a platinum catalyst and hydrogen to give 2-[(1-methylethyl)(phenylmethyl) amino]ethanol;

Sources & evidence

ORD record
ord-e5a212f1a1d24df68e9d64a90e5033fd
Source dataset
uspto-grants-1995_07
Patent number
US05432284

Reaction notes

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