2,2-Dimethoxypropane → HCID 22854594, compound

In 15 ml of dried methylene chloride was dissolved 2.32 g of 2-benzyloxycarbonyl-1-(benzyloxycarbonylmethyl)ethyl 2-deoxy-2-tetradecanoylamino-α-D-glucopyranoside, and 2.04 ml of 2,2-dimethoxypropane and 38 mg of camphorsulfonic acid were added thereto at room temperature, followed by stirring at room temperature for 15 hours. Further, 20 mg of camphorsulfonic acid and 2.04 ml of 2,2-dimethoxypropane were added thereto, and the stirring was continued for an additional period of 8 hours. The reaction mixture was neutralized with anhydrous potassium carbonate while stirring, washed successively with water and a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The resulting yellow oily substance was dissolved in 20 ml of dried methylene chloride, and 0.40 ml of pyridine, 0.61 g of N,N-dimethylaminopyridine, and 0.71 ml of benzyloxycarbonyl chloride were successively added thereto at room temperature, followed by stirring at room temperature for 12 hours. The reaction mixture was washed successively with 1N hydrochloric acid, water, and a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure. The resulting yellow oily substance was dissolved in 50 ml of a 90% acetic acid aqueous solution, and the solution was stirred at 90° C. for 30 minutes. After cooling, the solvent was removed by distillation under reduced pressure. Toluene was added to the residue and then removed by distillation under reduced pressure. Toluene addition and removal were repeated, and the resulting residue was purified by silica gel column chromatography (developing solvent: 5% acetone-containing chloroform, changed en route to 2% methanol-containing chloroform) to obtain a pale yellow oily substance. Recrystallization from hexane followed by filtration gave 2.42 g of the titled compound as a white solid. This solid could be recrystallized from hexane.

1. additionwere added
2. customat room temperature
3. waitthe stirring was continued for an additional period of 8 hours
4. stirringwhile stirring
5. washwashed successively with water
6. dry with materiala saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate
7. customThe solvent was removed by distillation under reduced pressure
8. dissolutionThe resulting yellow oily substance was dissolved in 20 ml of dried methylene chloride
9. addition0.40 ml of pyridine, 0.61 g of N,N-dimethylaminopyridine, and 0.71 ml of benzyloxycarbonyl chloride were successively added
10. customat room temperature
11. stirringby stirring at room temperature for 12 hours
12. washThe reaction mixture was washed successively with 1N hydrochloric acid, water
13. dry with materiala saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate
14. customThe solvent was removed by distillation under reduced pressure
15. dissolutionThe resulting yellow oily substance was dissolved in 50 ml of a 90% acetic acid aqueous solution
16. stirringthe solution was stirred at 90° C. for 30 minutes
17. temperatureAfter cooling
18. customthe solvent was removed by distillation under reduced pressure
19. additionToluene was added to the residue
20. customremoved by distillation under reduced pressure
21. additionToluene addition and removal
22. customthe resulting residue was purified by silica gel column chromatography (developing solvent: 5% acetone-containing chloroform, changed en route to 2% methanol-containing chloroform)
23. customto obtain a pale yellow oily substance
24. customRecrystallization from hexane
25. filtrationfollowed by filtration

ORD record

ord-16ac52d08d8e41ffba74647e2b44b4fc

Source dataset

uspto-grants-1995_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05432267