Dichloromethane → HCID 19921428, compound

HRID 1647895Notes

Reaction equation

HRID 1647895 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([CH2:14]CC3C=CC(OC)=C(OC)C=3)[C:12]3[CH:26]=[CH:27][C:28]([C:30]([NH:32][CH2:33][CH2:34][C:35]([O:37][CH3:38])=[O:36])=[O:31])=[CH:29][C:11]=3[N:10]=2)=[CH:5][CH:4]=1)#[N:2].C(N(CC)CC)C.[O:46]1[CH2:50][CH2:49][CH2:48][CH2:47]1.C(Cl)Cl.C(Cl)Cl.C[OH:58]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:13]([CH2:14][CH2:49][CH2:48][C:47]([O:46][CH3:50])=[O:58])[C:12]3[CH:26]=[CH:27][C:28]([C:30]([NH:32][CH2:33][CH2:34][C:35]([O:37][CH3:38])=[O:36])=[O:31])=[CH:29][C:11]=3[N:10]=2)=[CH:5][CH:4]=1)#[N:2]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 19921473HCID 19921473, compoundHCID 21226129Dichloromethane methanol

Product 1

HCID 19921428HCID 19921428, compound

Procedure

The same procedure is used as in (1) using triethylamine as auxiliary base. A 3:1 mixture of tetrahydrofuran and methylene chloride is used as solvent. Rf value: 0.68 (silica gel; methylene chloride/methanol=37:3)

Sources & evidence

ORD record
ord-c3bad4d3e9644085bf3bcd775d26e2ed
Source dataset
uspto-grants-1995_07
Patent number
US05434150

Reaction notes

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