Hydrochloric Acid → HCID 11448298, compound

HRID 1648738Notes

Reaction equation

HRID 1648738 reaction equation
[CH:1](=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[ClH:10].C([O:14][CH2:15][CH3:16])(=O)C>>[Cl-:10].[OH:14][C:15]1[CH:16]=[CH:1][C:2]([C:3]2[CH:5]=[CH:1][C:2]3[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=3)[O+:4]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6998SalicylaldehydeHCID 8857Ethyl Acetate

Product 1

HCID 11448298HCID 11448298, compound

Procedure

122 g of salicylaldehyde and 136 g of 4-hydroxy-acetophenone were dissolved in a four-necked one-liter flask equipped with a mechanical stirrer and containing 400 ml of anhydrous ethyl acetate. Under agitation and at room temperature, a stream of dry hydrochloric acid was passed into the solution in such manner that saturation was completed in the course of one hour. The mixture was left under agitation for 24 hours, during which precipitation of the reaction product began. Filtration was carried out, the product dried at 40° C. in the presence of KOH and recrystallisation carried out twice from methanol. There were obtained 179 g of 4'-hydroxyflavylium chloride.

Workup

  1. customequipped with a mechanical stirrer
  2. customat room temperature
  3. customwas completed in the course of one hour
  4. filtrationFiltration
  5. dry with materialthe product dried at 40° C. in the presence of KOH and recrystallisation

Sources & evidence

ORD record
ord-d39bd86d7f2a4365bdaacdd77e4c309c
Source dataset
uspto-grants-1983_11
Patent number
US04413004

Reaction notes

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