反应详情

To a mixture of 6-amino-8-methoxy-3,4-dihydrocarbostyril (12 g), concentrated hydrochloric acid (16 ml) and water (50 ml) was added ice (30 g), and sodium nitrite (5 g) and water (20 ml) were added gradually to the resulting mixture under ice-cooling. After completion of addition, the resulting mixture was reacted at 0° to 5° C. for 1 hour. On the other hand, a heated solution of acetaldehyde semicarbazide (10 g) in water (50 ml) and then sodium sulfite (0.25 g) and copper sulfate (3.2 g) were added to a solution of sodium acetate (34 g) in water (40 ml), and the internal bath was adjusted to a temperature of 10° to 20° C. The solution was stirred and below the surface of the solution was added gradually a solution prepared by adding a solution of sodium acetate (26 g) in water (46 ml) to the above diazonium salt solution. After stirring was continued for 2 hours, the reaction was allowed to stand for one night. Precipitates which formed were collected by filtration and washed with water. They were added in 200 ml of 2 N hydrochloric acid and the mixture was refluxed for 2 hours. After cooling, the reaction mixture was extracted with chloroform (150 ml) twice and the chloroform layer was washed with water. The solution was filtered through a short column charged with silica gel-activated carbon. This column was washed with 500 ml of chloroform. The two chloroform layers were combined and chloroform was evaporated. The residue was recrystallized from benzene to give 5.1 g of 6-acetyl-8-methoxy-3,4-dihydrocarbostyril.

1. additionwere added gradually to the resulting mixture under ice-
2. temperaturecooling
3. additionAfter completion of addition
4. customthe resulting mixture was reacted at 0° to 5° C. for 1 hour
5. customwas adjusted to a temperature of 10° to 20° C
6. additionwas added gradually a solution
7. customprepared
8. stirringAfter stirring
9. waitto stand for one night
10. customPrecipitates which
11. customformed
12. filtrationwere collected by filtration
13. washwashed with water
14. additionThey were added in 200 ml of 2 N hydrochloric acid
15. temperaturethe mixture was refluxed for 2 hours
16. temperatureAfter cooling
17. extractionthe reaction mixture was extracted with chloroform (150 ml) twice
18. washthe chloroform layer was washed with water
19. filtrationThe solution was filtered through a short column
20. additioncharged with silica gel-activated carbon
21. washThis column was washed with 500 ml of chloroform
22. customchloroform was evaporated
23. customThe residue was recrystallized from benzene