反应详情

A suspension of 1.0 g of 6-(1-piperazinyl)-3,4-dihydrocarbostyril monohydrobromide in 10 ml of DMF was added 296 mg of sodium hydrogencarbonate and stirred at room temperature for 30 minutes to convert the compound to 6-piperazinyl-3,4-dihydrocarbostyril, to which was added 0.62 ml of triethylamine. Then, a solution of 605 mg of 4-acetyloxybenzoyl chloride in 5 ml of DMF was slowly added dropwise to the mixture. After completion of addition, the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into a large amount of water and extracted with chloroform. The extract was washed serially with saturated aqueous sodium hydrogencarbonate solution and with water and then dried over anhydrous sodium sulfate. Chloroform was distilled off to give 6-[4-(4-acetyloxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril.

1. additionAfter completion of addition
2. stirringthe mixture was stirred at room temperature for 1 hour
3. extractionextracted with chloroform
4. washThe extract was washed serially with saturated aqueous sodium hydrogencarbonate solution and with water
5. dry with materialdried over anhydrous sodium sulfate
6. distillationChloroform was distilled off