反应详情

A solution of 2-benzhydryloxycarbonyl-7-t-butoxycarbonylamino-3-(2,2-dichloroethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-5-oxide (product 11f) (3.3 g) and triethylamine (0.88 cc) in dry tetrahydrofuran (50 cc) is stirred at 25° C. for 16 hours and the reaction mixture is then diluted with ethyl acetate (200 cc). The organic solution is washed with distilled water (5×60 cc), dried over sodium sulphate and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 35° C. This yields a product (11e) (3.1 g) in the form of a hard orange foam.

1. washThe organic solution is washed with distilled water (5×60 cc)
2. dry with materialdried over sodium sulphate
3. concentrationconcentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) at 35° C