反应详情

65 g of 2,6-dimethylphenol are dissolved in 200 ml of dry DMF and, under N2, 23.2 g of a 55% suspension of sodium hydride in mineral oil are added in portions. Then 50.4 ml of methyl bromoacetate are added dropwise with stirring, and the mixture is left to stand overnight. The precipitated salt is filtered off with suction, and the filtrate is concentrated. The residue is taken up in ethyl acetate, and the solution is extracted with water. The organic phase is dried over magnesium sulfate and concentrated. An oily liquid remains and is used directly in the following reaction.

1. waitthe mixture is left
2. filtrationThe precipitated salt is filtered off with suction
3. concentrationthe filtrate is concentrated
4. extractionthe solution is extracted with water
5. dry with materialThe organic phase is dried over magnesium sulfate
6. concentrationconcentrated
7. customis used directly in the following reaction