HRID1650645

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID301

2-Chloro-1,4-hydroquinone

C6H5ClO2

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

HCID23052179

1-(Bromomethyl)-4-(dodecyloxy)benzene

C19H31BrO

PRODUCTS

生成物

结构：CCCCCCCCCCCCOc1ccc(Cc2c(O)ccc(Oc3ccc(O)c(Cc4ccc(OCCCCCCCCCCCC)cc4)c3Cl)c2Cl)cc1

HCID56975878

未命名化合物

PROCEDURE

实验过程

In an aqueous solution of sodium hydroxide, 2.0 g of 4-dodecyloxybenzyl bromide synthesized in the same manner as described in Referential Example 17 was reacted under reflux with 1.0 g of 4-hydroxy-3-chlorophenol for 8 hours, the thus-obtained solution was put into ice-cooled hydrochloric acid, and the precipitate was recovered by filtration, washed, dried and purified by the silica gel column chromatography to obtain 0.8 g of 4-dodecyloxybenzyl(4-hydroxy-2-chlorophenyl) ether.

WORKUP

后处理

customwas reacted
filtrationthe precipitate was recovered by filtration
washwashed
customdried
custompurified by the silica gel column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-01eaf141db0c4242a015161c5ff95c91
来源数据集: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04925591
来源说明: uspto-grants-1990_05

反应 SMILES

[OH-:1].[Na+].[CH2:3]([O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]Br)=[CH:18][CH:17]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[OH:24][C:25]1[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][C:26]=1[Cl:32].[ClH:33]>>[CH2:3]([O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][C:16]2[C:17]([Cl:33])=[C:18]([O:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([CH2:20][C:19]4[CH:22]=[CH:23][C:16]([O:15][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[CH:17][CH:18]=4)[C:26]=3[Cl:32])[CH:19]=[CH:22][C:23]=2[OH:1])=[CH:18][CH:17]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]